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High fish consumption key route to heart health. (Several Studies Support Fish Oil Effect).
SNOWMASS, COLO. -- "If you really want to do something heart healthy for yourself, either eat a little fish every day or take a gram or two of dietary fatty acid--rich fish oil capsules," Dr. Robert A. Vogel advised at a conference sponsored by the American College of Cardiology.
The data to support the benefits of this approach are persuasive. If they had been generated in studies of an investigational drug, that medication would sail through the Food and Drug Administration's approval process in a couple of weeks, quipped Dr. Vogel, the Herbert Berger Professor of Medicine and head of the division of cardiology at the University of Maryland, Baltimore.
Most experts attribute the cardiovascular benefits associated with fish consumption to the omega-3 fatty acids. The cardiovascular benefits of fish oils are supported by observational epidemiologic studies as well as multiple landmark dietary intervention trials. There is also a biologically plausible hypothesis to explain the effects: Omega-3 fatty acids have been shown to enhance endothelial function, reduce platelet aggregation, and stabilize cell membranes.
Last year, Danish investigators reported finding a strong independent correlation between heart rate variability in 291 patents suspected of having ischemic heart disease and dietary intake of n-3 polyunsaturated fatty acids (PUPA) derived from fish as well as n-3 PUFA levels in granulocyte membranes and adipose tissue. This increased heart rate variability implies an antiarrhythmic effect that may explain the reduction in sudden cardiac death previously observed in patients who regularly eat fish or fish oil (Circulation 103[5]:651-57, 2001).
In the Italian GISSI Prevention Study, more than 11,300 post-MI patients were randomized to either 1 g/day of omega-3 fatty acids in fish ...
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Source: HighBeam Research, High fish consumption key route to heart health. (Several Studies...