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Several factors raise failure rate of pyelonephritis Tx. (Recent Antibiotic Use or UTI).
CHICAGO -- Recent antibiotic use, a recent urinary tract infection, and treatment of less than 10 days' duration significantly increase the risk for treatment failure in community-acquired pyelonephritis, Anita G. Carrie said at the annual Interscience Conference on Antimicrobial Agents and Chemotherapy sponsored by the American Society for Microbiology.
Increasing resistance among uropathogens to trimethoprimsulfamethoxazole (TMP-SMX) is believed to decrease the effectiveness of this agent relative to the fluoroquinolones in treating community-acquired pyelonephritis. In a recent Canadian study 19.2% of outpatient uropathogens were resistant to TMP-SMX, compared with just 1.8% resistance to ciprofloxacin (Antimicrob. Agents Chemother. 44[4]:1089-92, 2000).
However, such data may not reflect what happens in routine clinical practice, noted Ms. Carrie of the University of Manitoba, Winnipeg.
In an observational review of health insurance claims for 1,361 ...
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Source: HighBeam Research, Several factors raise failure rate of pyelonephritis Tx. (Recent...