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NEW ORLEANS -- Women who are diagnosed with cancer while pregnant can be reassured that they are not at increased risk for preterm delivery or intrauterine growth restriction, even if chemotherapy is required.
"They do well and their babies do well," Dr. Elyce Cardonick said at the annual meeting of the Society for Maternal-Fetal Medicine.
Reporting on a group of 48 pregnant women diagnosed with several different types of malignancy and followed prospectively, Dr. Cardonick said that the mean gestational age at delivery was 37.4 weeks, and the mean birth weight was 2,798 g. Only two infants (4.2%) were below the 10th percentile for weight, and only four patients (8.3%) delivered before 35 weeks.
The most common diagnosis was breast cancer (21 women), followed by melanoma (5), thyroid cancer (4), central nervous system malignancy (4), and Hodgkin's lymphoma (4). There were two cases each of ovarian cancer and leukemia, and one each of lung, vulvar, cervical, colon, and bladder cancer as well as one non-Hodgkin's lymphoma.
Chemotherapy proved to be safe in this group of patients "and should not be avoided in indicated cases of cancer diagnosed in pregnancy," Dr. Cardonick said, noting that 22 women underwent chemotherapy after the first trimester, beginning at a mean gestational age of 20.7 weeks.
Agents used included doxorubicin, cyclophosphamide, pad taxel, bleomycin, cisplatin, and vinblastine. The mean number of treatments was 4.4, said Dr. Cardonick of the division of maternal-fetal medicine, department of obstetrics and gynecology, Jefferson Medical College, ...