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Tamoxifen decreases the incidence of benign breast disease. (Adenosis, Cysts).
SAN ANTONIO -- Tamoxifen markedly reduces the incidence of most forms of benign breast disease, Dr. Elizabeth Tan-Chiu said at the annual breast cancer symposium sponsored by the San Antonio Cancer Institute.
She reported on 13,388 women at high risk for developing breast cancer who were randomized to tamoxifen or placebo in the National Surgical Adjuvant Breast and Bowel Project Breast Cancer Prevention Trial (NSABP BCPT P-1). In 1998 this landmark trial demonstrated that tamoxifen reduced the incidence of invasive breast cancer by 49% and of noninvasive cancer--ductal carcinoma in situ and lobular carcinoma in situ--by 50%.
Now NSABP P-1 investigators have turned their attention to benign breast disease. At a median 54.6 months of follow-up, the overall risk of benign breast disease in the tamoxifen-treated group was reduced by 28%, compared with women on placebo, reported Dr. Tan-Chiu of the NSABP operations office in Pittsburgh.
Total breast biopsies were 22% fewer in the tamoxifen group than the 1,804 biopsies performed in controls. Moreover, the use of tamoxifen reduced by 12% the number of women who experienced at least one biopsy, from 1,242 to 1,098.
"The finding of a tamoxifen effect in benign breast tissue supports its ...
- ASCEND Therapeutics Files Patent Applications for Drug Planned to Treat Benign...
- Press release article from: PR Newswire August 12, 2004 700+ words
...use for the treatment of benign breast disease. The patents provide protection...of chronic conditions like benign breast disease, and solidify the company...experience a first incidence of benign breast disease. The term benign breast...
- ASCEND FILES PATENT FOR BENIGN BREAST DISEASE DRUG.
- Newspaper article from: Biotech Business October 1, 2004 700+ words
...use for the treatment of benign breast disease. The patents provide protection...of chronic conditions like benign breast disease, and solidify the company...experience a first incidence of benign breast disease. The term benign breast...
- ASCEND Therapeutics files patent applications for drug planned to treat benign...
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...use for the treatment of benign breast disease. The patents provide protection...of chronic conditions like benign breast disease, and solidify the company...experience a first incidence of benign breast disease. The term benign breast...
- Benign Breast Disease.(imaging diagnosis)
- Magazine article from: Radiologic Technology NORRIS, TERESA G. January 1, 2001 700+ words
...breast cancer, but instead have a benign breast disease.[1] Loosely defined, benign breast disease encompasses any disease or breast...carcinoma.[2] More specifically, benign breast disease refers to a range of mammographic...
- Diet and supplements for benign breast disease.(Nutritional Influences on...
- Magazine article from: Townsend Letter Werbach, Melvyn R. April 1, 2009 700+ words
...from fat and the risk of benign breast disease. (1) When 121 patients...unrelated to the risk of benign breast disease, while there were positive...found no increase in risk of benign breast disease with increasing fat intake...
- Postmenopausal Hormone Therapy and Benign Breast Disease.
- Magazine article from: OB/GYN Clinical Alert September 1, 1999 700+ words
...Postmenopausal Hormone Therapy and Benign Breast Disease Abstract & Commentary...women with biopsy-proved benign breast disease. Source: Dupont WD, et...cancer in women with true benign breast disease, and that hormone therapy...
- Patent application filed for TamoGel for treatment of benign breast disease.
- Newspaper article from: Biotech Business Week September 6, 2004 700+ words
...use for the treatment of benign breast disease. The patents provide protection...of chronic conditions like benign breast disease, and solidify the company...proven to reduce the risk of benign breast disease by 28%. The same study...
- There is a relationship between benign breast disease and breast cancer risk.
- Newspaper article from: Health & Medicine Week July 28, 2003 700+ words
...is a relationship between benign breast disease and breast cancer risk...of histologically proven benign breast disease and breast cancer risk and...the histologic category of benign breast disease. "In particular, proliferative...
