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Epilepsy, valproate cause ovulatory failure. (55% Prevalence).
PHILADELPHIA -- Epilepsy can deliver a double anovulatory whammy to women.
First, epilepsy itself appears to boost a woman's risk of ovulatory failure. Second, treatment with valproate, a commonly used antiepilepsy drug, appears to make an independent contribution to ovulatory failure, Dr. Martha J. Morrell said during the joint meeting of the American Epilepsy Society and the American Clinical Neurophysiology Society.
In a study with 94 women with epilepsy and 23 control women, those with primary generalized epilepsy (PGE) who were also treated with valproate had a 55% prevalence of ovulatory failure, said Dr. Morrell, a professor of neurology at Columbia University in New York.
In contrast, the rate of ovulatory failure among control women was 10.9%, a rate that's typical for the general population of women of reproductive age.
"The epilepsy syndrome and valproate treatment may interact to potentiate the reproductive disturbance," she said.
Dr. Morrell and her associates studied women aged 18-40 (mean age of 31 years) who had epilepsy for an average of 14 years. The women were examined prospectively over the course of 3 months. Among the women with seizure disorder, 59 had localization-related epilepsy (LRE) and 35 had PGE.
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Source: HighBeam Research, Epilepsy, valproate cause ovulatory failure. (55% Prevalence).