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19 postmenopausal women studied: cortisol may mediate effect of depression on osteoporosis.(Gynecology)
BALTIMORE -- Women with a depression history appear to have increased stress-related cortisol levels, a finding that may help explain the link between depression and osteoporosis, according to data presented at the annual meeting of the American Association for Geriatric Psychiatry.
Women with a history of depression had higher salivary cortisol levels in response to a stress-inducing situation than women without a history of depression, Patricia M. Furlan, Ph.D., of the University of Pennsylvania, Philadelphia, said in a poster presentation. The researchers also found that ever-depressed women also had lower bone mineral density (BMD) than never-depressed women.
The study involved 19 postmenopausal women (over age 50 years) recruited from a prior radiology study who had been assessed for BMD in the past year. During the first visit, the women were assessed for a history of depression using several standardized tools. Ten of the women had no history of depression and nine did.
At the second visit, the women were asked to deliver a speech on the topic of their greatest success or failure. They were given a short period of time alone to prepare their speech and then were instructed to deliver it in front of a two-way mirror, knowing that they were being observed. Four saliva ...
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