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Long-term OCs can prevent endometrioma recurrence.(GYNECOLOGY)(Clinical report)
LAS VEGAS -- After laparoscopic cystectomy, the long-term use of oral contraceptives can effectively prevent recurrence of ovarian endometrioma, based on results from a single-center study.
In the 2-year study of 217 patients, two groups got either cyclic or continuous oral contraceptives after laparoscopic cystectomy, and one group went untreated.
The recurrence rate for endometriomas was 29% in the untreated group, a rate that was significantly higher than the recurrence rates in the groups who took OCs.
"Oral contraceptive pills can provide a better option in terms of safety, tolerability, and cost" than do other hormones for adjuvant therapy following laparoscopic surgery, Dr. Mohamed Mabrouk said at the annual meeting of the AAGL. "However, data from clinical trials on this topic are few and controversial."
In one cohort study, long-term exposure to oral contraceptives after conservative surgery for ovarian endometriosis was associated with a major reduction in the risk of endometrioma recurrence, with a gradient effect observed with regard to duration of treatment (Am. J. Obstet. Gynecol. 2008;198:504.el-5).
Although researchers in an earlier retrospective study found that treatment with oral contraceptives for a mean of 9.5 months after laparoscopic excision did not significantly influence endometrioma recurrence, they did suggest that a longer period of treatment might prevent recurrence (Hum. Reprod. 2006;21:2171-4).
The only published, randomized, controlled trial on the topic demonstrated that the postoperative cyclic use of OCs does not significantly influence longterm, endometrioma recurrence rates (Am. J. Obstet. Gynecol. 2000;183:588-92).
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