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At age 30-plus, IBD spurs primordial follicles' loss.(Gynecology)(Clinical report)
San Francisco -- Inflammatory bowel disease does not severely alter ovarian reserve but may accelerate loss of primordial follicles in those aged 30 years and older, results from a clinical study showed.
The investigators measured anti-mullerian hormone--which is a reliable hormonal marker for evaluating ovarian reserve independently of the menstrual cycle--in 44 women aged 20-41 years who had IBD and were in clinical remission after infliximab treatment for either Crohn's disease (37 patients) or ulcerative colitis (in 7 patients).
The hormone levels were compared with those of 163 age-matched women undergoing in vitro fertilization who had a normal ovarian response to controlled ovarian stimulation (5-15 oocytes retrieved) and a normal serum anti-mullerian hormone level (greater than 1.5 mcg/L).
The anti-mullerian hormone levels did not differ significantly overall between the IBD and control patients (2.72 vs. 2.12 mcg/L), Dr. Thomas Freour reported in a poster at the annual meeting of the American Society for Reproductive Medicine.
However, when the women were stratified by age 30 years and older versus ...
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Source: HighBeam Research, At age 30-plus, IBD spurs primordial follicles'...