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The hero of "Synecdoche, New York" is a theatre director named Caden Cotard (Philip Seymour Hoffman). He runs a successful troupe in Schenectady--so successful that he receives an award from the MacArthur Foundation, giving him carte blanche to unleash his genius at will. This is a rare palliative for Caden, the rest of whose existence is a rash of displeasure and doom. His wife, Adele (Catherine Keener), is a painter of canvases so minuscule that viewers must wear magnifying spectacles to see them. She is also a top-class moper, sprawling across the couch when they go to counselling. "Can I say something awful?" she asks the therapist, a blonde of terrifying perkiness ...