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Obesity may raise risk for infant hydrocephaly: preliminary analysis.(Obstetrics)
SAN FRANCISCO -- Maternal obesity may increase the risk for infant hydrocephaly, D. Kim Waller, Ph.D., reported at the annual meeting of the American Public Health Association.
This preliminary finding is among several that were generated from separate analyses of data from the ongoing National Birth Defects Prevention Study, a multicenter case-control study of more than 30 birth defects. From 1997 to 2000, the study investigators interviewed and obtained buccal swabs from 7,470 women with congenitally malformed infants and 3,821 controls with normal infants to compare genetic and environmental factors. The study is funded by the Centers for Disease Control and Prevention.
Although the investigators cautioned that few conclusions can be drawn from these preliminary analyses of data subsets, some interesting findings are starting to emerge. Here are some highlights:
* Maternal obesity. Women with a body mass index of 30 or greater were shown to have a doubled risk for infant hydrocephaly after controlling for other factors. This supports a previous but not yet published finding made from Texas state data, said Dr. Waller of the University of Texas, Houston.
Heavy but not quite obese women with a body mass index of 27-29 also had a doubled risk for infant hydrocephaly, compared with normal-weight women. In the national data, the risk for hydrocephaly also increased in lean women, compared with normal-weight women--an unconfirmed finding that Dr. Waller has not seen before in previous research.
Obesity was linked to a twofold increase in the risk for spina bifida and seemed to increase the risk for anencephaly by 40%, though the latter finding did not reach statistical significance. Both findings are supported by conclusions from nine previous studies, she said.
* Congenital heart ...
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Source: HighBeam Research, Obesity may raise risk for infant hydrocephaly: preliminary...