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Drug-induced liver disease with citalopram.(Case Report)(Case study)(Brief article)

Brown University Psychopharmacology Update

| May 01, 2008 | COPYRIGHT 2008 Wiley Periodicals, Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

Patient: Female, 56 years old

Medications: Citalopram (Celexa)

Comment: A 56-year-old woman presented with weakness, asthenia, weight loss and jaundice. She was taking citalopram (Celexa) 20 mg/day for three weeks. She reported no alcohol or drug use and no blood transfusions. She had no history of liver disease. A physical exam revealed a mild hepatomegaly without signs of chronic liver disease. Abdominal ultrasound suggested an acute hepatitis. Because the etiology of the acute liver injury was unclear, a biopsy was performed. Histology was consistent with a drug-induced liver injury with subacute liver dystrophy and liver cell necrosis. Treatment with…

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