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ATLANTA -- Combination antiretroviral therapy today is sufficiently effective that elective cesarean section is not always required to prevent vertical transmission in HIV-infected pregnant women.
During the 1990s a European randomized clinical trial and a metaanalysis of 15 prospective cohort studies both determined that elective cesarean delivery significantly lowered the risk of maternal-fetal HIV transmission. More recent work, however, taking into account the effects of widespread zidovudine use for the prevention of perinatal transmission, suggests that if the woman's viral load is below 1,000 copies of RNA per mL at the time of delivery there is no difference in risk of transmission between elective cesarean section and vaginal delivery, Dr. Michael K. Lindsay said at a conference on high-risk obstetrics sponsored by Symposia Medicus.
In a study undertaken by the Pediatric AIDS Clinical Trials Group of the National Institute of Child Health and Human Development, 497 HIV-infected women were enrolled and levels of HIV RNA, CD4+ lymphocytes, and p24 antibodies were determined at baseline and delivery. There were no instances of perinatal transmission among women whose HIV RNA ...
Source: HighBeam Research, C-section optional if maternal HIV load is low: below 1,000...