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Oocyte cryopreservation now feasible, expert says: especially oncology patients.(News)

OB GYN News

| December 01, 2003 | Johnson, Kate | COPYRIGHT 2003 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

SAN ANTONIO -- Oocyte cryopreservation, once considered highly experimental, should now be presented as a viable option to women--especially oncology patients, according to one of the leading experts in this procedure.

"Now this technique is feasible," said Dr. Eleonora Porcu of the department of ob.gyn. at the University of Bologna (Italy).

"It is important to deliver the message that this is a new opportunity that might be the most reliable thing for your oncology patients. Women who previously had no options can now benefit from oocyte cryopreservation," Dr. Porcu said at the annual meeting of the American Society for Reproductive Medicine.

Her center, which provides oocyte cryopreservation for patients before they undergo cancer treatment, has now documented 60 pregnancies and 33 babies born as a result of this technique.

Although the first birth from a cryopreserved oocyte was announced in 1986, subsequent success with the technique has been very poor worldwide. "The general opinion has been that oocyte cryopreservation is inefficient, unreliable, and unsafe," she said.

Survival of thawed oocytes has historically been very poor because of damage caused by the freezing technique, as well as the cryoprotectants used. Additionally, there has been debate over the level of chromosomal abnormalities caused by damage to the meiotic spindle that might be present in cryopreserved oocytes.

"Damage may also be present in both the zona pellucida and cortical granules of these oocytes," she said.

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