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DALLAS -- Diabetic nephropathy does not appear to be adversely affected by pregnancy but pregnancy can most definitely be adversely affected by diabetic nephropathy Pregnant patients with diabetic nephropathy have a greater risk of delivering a preterm or low-birth-weight baby They also have a greater risk of preeclampsia and cesarean section--particularly if glucose is poorly controlled, Dr. Ajay Singh said at a meeting on clinical nephrology sponsored by the National Kidney Foundation.
Spontaneous abortion rates in patients with HCG-positive pregnancy are 25% in the nondiabetic population and 32% in diabetic nephropathy patients with poor glycemic control. Twenty percent to 30% of congenital anomalies result in perinatal deaths in the general population, compared with 50% of congenital anomalies in those with diabetic nephropathy.
Furthermore, the fetal malformation rate is 25% in diabetic nephropathy patients with poor glycemic control; this can be reduced to less than 8% with prepregnancy counseling. Such counseling, along with good glycemic control and eye care throughout pregnancy is ...