AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Cardiac event risk low in young, healthy HRT users: WHI findings may not apply to healthy women treating menopausal symptoms. (Four Large, Randomized Trials).
NEW ORLEANS -- The overall risk of cardiovascular events is extremely low in healthy women in early menopause who rely on hormone therapy to treat their menopausal symptoms, according to pooled data from four large randomized clinical trials.
These findings contrast with those from other recent trials showing increased risk of coronary disease in the first year of hormone replacement therapy (HRT) in women using certain regimens. The new findings suggest that those from the widely publicized Women's Health Initiative (V/HI) study and the Heart and Estrogen/Progestin Replacement Study (HERS), for example, do not apply to younger postmenopausal women taking hormones for treatment of menopausal symptoms, Dr. Rogerio Lobo reported in a poster session at the annual meeting of the American College of Obstetricians and Gynecologists.
The average age of patients in the WHI was 67 years, and that in HERS was 63 years. Women in those studies were not using hormones for the treatment of menopausal symptoms. The average age of patients in the current study was 53 years, said Dr. Lobo of Columbia-Presbyterian Medical Center, New York.
In the WHI, the hazard ratio for cardiovascular events in women aged 50-59 was 1.67. The annual event rate, based on first-year findings, would be 2.23 per 1,000 HRT users--a markedly higher rate than the 0.17 events per 1,000 patient years noted in the current study.
The data used in Dr. Lobo's study came from the Women's Health, Osteoporosis, Progestin, Estrogen study (Fertil. Steril. 75:1065-79, 2001), the Menopause Study Group (Obstet. Gynecol. 83[5 pt. 1]:686-92, 1994), and two studies on file at Wyeth Research (Philadelphia), which sponsored Dr. Lobo's study.
Various hormonal regimens were used in these studies, including conjugated equine estrogen (CEE) alone, CEE plus medroxyprogesterone acetate, CEE with trimegestone, estradiol-17[beta] with trimegestone, and estradiol-17[beta] with ...
- Commercial And Pipeline Insight: HRT For Menopausal Symptoms A New Class...
- Press release article from: M2 Presswire June 17, 2008 700+ words
...And Pipeline Insight: HRT For Menopausal Symptoms A New Class Restores An...And Pipeline Insight: HRT For Menopausal Symptoms - A New Class Restores...the market value of HRT for menopausal symptoms saw its first upturn since...
- Commercial and Pipeline Insight: HRT for Menopausal Symptoms - A New Class...
- Press release article from: Business Wire June 17, 2008 700+ words
...Pipeline Insight: HRT For Menopausal Symptoms - A New Class Restores...market value of HRT for menopausal symptoms saw its first upturn...future size of the HRT market and the...for treatment for menopausal symptoms in the US, 5EU...
- Long-term use of combo HRT: risks outweigh benefits; experts say that...
- Magazine article from: OB GYN News Mechcatie, Elizabeth August 1, 2002 700+ words
...room for short-term use of combination HRT for the treatment of menopausal symptoms. The WHI study did not evaluate the use of combination HRT on menopausal symptoms, but it has been shown to be effective...
- HRT can benefit women with menopausal symptoms, harm those without.
- Magazine article from: Women's Health Weekly March 4, 2004 700+ words
...replacement therapy (HRT) can help women experiencing menopausal symptoms, but women free of...50, with or without menopausal symptoms, who had used combined HRT for 5 years. In women free of menopausal symptoms, the analysis showed...
- Zoe Foods Providing Natural HRT Alternative; Cereals and Bars Relieve...
- Press release article from: PR Newswire July 11, 2002 700+ words
...of a major study on the effects of HRT due to shocking findings about increased...seeking other ways to relieve their menopausal symptoms. Zoe Foods Flax & Soy Granola...helped thousands of women overcome their menopausal symptoms. Soy and flaxseed both contain natural...
- HRT pros, cons should be considered for women with severe menopausal symptoms.
- Newspaper article from: Health & Medicine Week March 8, 2004 700+ words
...benefits of hormone replacement therapy (HRT). "We're saying that physicians have...trials. "There are many women for whom HRT continues to be an excellent choice for...practice, I'm putting a lot of women back on HRT." One of the WHI clinical trials, which...
- Discontinued Use of HRT Drug Prempro May Cause Menopausal Symptoms to Reoccur;...
- Press release article from: PR Newswire July 30, 2002 700+ words
...symptoms related to menopause, such as vaginal dryness, increase when they stop using Prempro, a hormone replacement therapy (HRT). Considered one of the most irritating and painful symptoms of menopause, untreated vaginal dryness can lead to vaginitis...
- Stakeholder Opinions - Non-hormonal Treatments for Menopausal Symptoms.
- Press release article from: M2 Presswire October 9, 2008 700+ words
...Treatments for Menopausal Symptoms Introduction - The treatment of menopausal symptoms is a common clinical...replacement therapy (HRT) has formed...wish to receive HRT due to safety...treatment of menopausal symptoms.. Explore the...
Source: HighBeam Research, Cardiac event risk low in young, healthy HRT users: WHI findings may...