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Somavert. (New & Approved: Albumin Cobalt Binding Test, Somavert).
(pegvisomant for injection, Pharmacia)
A growth hormone receptor antagonist for acromegaly, in people who have had an inadequate response to existing treatments (surgery, radiation treatment, and other medical therapies), or when these treatments are not appropriate. The first drug in this new class of drugs to be approved.
* Recommended Dosage: Subcutaneous 40-mg loading dose, followed by a 10-mg subcutaneous injection daily, adjusting dose based on serum insulin-like growth factor-I (IGF-I) levels, with dose not to exceed 30 mg a day.
* Special Considerations: Injection site reactions, sweating, headache, and fatigue were the most common side effects associated with treatment in trials. Monitor liver function for the first 6 months of therapy; in trials, two patients (fewer than 1%) had liver function tests above 10 times the upper limit of normal.
* Comment: The goal of treatment with ...
- Target growth hormone doses to IGF-1 levels.(News)(insulin-like growth factor 1)
- Magazine article from: Pediatric News Bates, Betsy October 1, 2005 700+ words
...adjustable doses of growth hormone based on their IGF-1 levels at 3...received enough growth hormone to drive their IGF-1 levels two standard...in the amount of growth hormone required to maintain targeted IGF-1 levels among...
- Tercica Announces Agreement with Genentech for Worldwide Growth Hormone and...
- Press release article from: Business Wire July 10, 2007 700+ words
...patients with low IGF-1 levels and...associated with growth hormone deficiency...IGF-1). IGF-1 is the direct mediator of growth hormone's (GH) effect...disorder, low IGF-1 levels are due to growth hormone resistance associated...
- Insmed Acquires IGF-1 Regulatory Files for Growth Hormone Insensitivity...
- Press release article from: Business Wire October 7, 2002 700+ words
...Like Growth Factor-1 (IGF-1) for the treatment of Growth Hormone Insensitivity Syndrome (GHIS...produce adequate quantities of IGF-1 due to a defect in the growth hormone signal. In GHIS patients, IGF-1 deficiency results in a...
- Results of Phase I and Phase IIa Clinical Studies Confirm the Inhibitory Effect...
- Press release article from: Business Wire July 16, 2009 700+ words
...significant reductions in IGF-1 levels were observed...maximum reduction in growth hormone (GH) levels compared...Additionally, a reduction in IGF-1 levels was seen in...included serum levels of IGF-1, prolactin, pharmacokinetics...over-production of growth hormone or ...
- Rethinking hormone therapy strategies: Rationale for homeopathic hGH and...
- Magazine article from: Townsend Letter for Doctors and Patients Brewitt, Barbara February 1, 2002 700+ words
...resistance. Typically, HRT involves multiple hormones such as growth hormone, thyroid hormones, cortisol, testosterone, estrogen, and...administration of hGH and insulin-like growth factor-1 (IGF-I). Naturopaths frequently use the same paradigm of HRT...
- Dosing growth hormones to IGF-1 levels more effective.(Metabolic Disorders)
- Magazine article from: Family Practice News Bates, Betsy November 15, 2005 700+ words
...adjustable doses of growth hormone based on IGF-1 levels at 3...received enough growth hormone to drive their IGF-1 levels two standard...seen in the amount of growth hormone required to maintain targeted IGF-1 levels among individual...
- Genentech Licenses IGF-I to Tercica Medica, Inc.; Tercica Closes $21.5 million...
- Press release article from: Business Wire May 23, 2002 700+ words
...resistance to the effects of growth hormone. IGF-I deficiency results in...scientists in the field of growth hormone and IGF-I, including Dr. Bengt...including many in the area of growth hormone, IGF-I and BP3. Dr. Clark was...
- FDA Approves Tercica's Increlex for Short Stature Caused by Severe Primary...
- Press release article from: PR Newswire August 31, 2005 700+ words
...severe primary IGF-1 deficiency...IGFD) or with growth hormone (GH) gene deletion...stimulation by growth hormone. Without adequate IGF-1, children...know that while growth hormone is critical, it is IGF-1 that is the...
Source: HighBeam Research, Somavert. (New & Approved: Albumin Cobalt Binding Test, Somavert).