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Untreated hypertension ups IUGR risk by two- to threefold. (Chronic Condition).
CANCUN, MEXICO -- Chronic, untreated hypertension is the most common maternal cause of intrauterine growth restriction.
About 3%-7% of pregnant woman have untreated, chronic hypertension, which makes it the most common medical complication of pregnancy, Dr. John T. Queenan said at a conference on obstetrics, gynecology, perinatal medicine, neonatology, and the law.
Untreated hypertension boosts the risk of intrauterine growth restriction (IUGR) from two- to threefold through several mechanisms, including decidual vasculopathy, a prematurely "aged" placenta with thickened basement membranes in terminal villi, and impaired blood flow from the uterus to the placenta. These effects are treatable and reversible by reducing the woman's blood pressure, said Dr. Queenan, a professor of ob.gyn. at Georgetown University in Washington.
Other notable maternal causes of IUGR include antiphospholipid syndrome, inherited thrombophilias, and substance abuse. Smoking more than 11 cigarettes a day raises the risk of IUGR from three to five times.
Fetal causes of IUGR include genetic abnormalities, structural abnormalities, and multiple gestation. Placental causes include placental separation, an infarction, abnormal placentation, and congenital ...
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...colleagues. "Intrauterine growth retardation (IUGR) ... is not a specific disease entity...in placental tissues from patients with IUGR. "We also observed enhanced mRNA expression...patients," the researchers reported. In IUGR and normal placenta, angiogenin stained...
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...and intrauterine growth restriction (IUGR) are characterized by morphological variations...normal (n=14), PE (n=16), and IUGR pregnancies (n=11), and their responses...differentiation was significantly enhanced in PE and IUGR," reported Crocker's team. "Responses...
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...term had a substantially increased risk of IUGR, compared with controls (odds ratio 8...were born preterm had no increased risk of IUGR, compared with controls (odds ratio 0...University. These findings are based on an IUGR cutoff value of less than the first percentile...
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...This intra-uterine growth retardation (IUGR) was significantly inhibited by general...general anesthesia alone induced significant IUGR (p<.0001) when compared with...the most sensitive tool for the study of IUGR." Their study appeared in the Journal...
