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Studies: estrogen may not slow cognitive declines. (Doesn't Appear to Help Memory).
High levels of endogenous or exogenous estrogens do not slow the decline of memory and cognition in older women with or without dementia, according to two studies.
A study of 202 men and 210 postmenopausal women without dementia examined the impact of high levels of endogenous estrogens on hippocampal volume and memory performance.
Women with estradiol levels in the highest third had significantly smaller hippocampal volumes determined by MRI scans than women with levels in the lowest third. The association was significant for both total and bioavailable estradiol levels after adjusting for age at the time of venipuncture, education, smoking, alcohol use, body mass index, depressive symptoms, apolipoprotein E genotype, type of menopause, age at menopause, and the use of hormone replacement therapy (HRT) in the past. The associations were strongest in the oldest age groups (Arch. Neurol. 60[2]:213-20, 2003).
The estradiol levels in men had no relationship to hippocampal volumes, reported lead investigator Dr. Tom den Heijer of Erasmus University, Rotterdam, the Netherlands, and his colleagues.
In women, a decline in delayed recall was significantly associated with bioavailable estradiol levels in the highest third, compared with the lowest third. The associations were strongest in the oldest women.
Men with total estradiol levels in the highest third followed a trend toward a decline in delayed recall, compared with men with levels in the lowest third, but the association was not significant.
Estrogen receptors are concentrated heavily in the hippocampus, which plays a primary role in memory function and is one of the first regions affected by Alzheimer's disease. Previous studies that suggested a preventive effect of estrogens on dementia were ...
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Source: HighBeam Research, Studies: estrogen may not slow cognitive declines. (Doesn't Appear to...