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NEW ORLEANS -- Smokers with locally advanced cervical cancer have significantly worse outcomes than nonsmokers, a recent study suggests.
Of 315 patients with previously untreated stage IIB, IIIB, or IVA cervical cancer who were followed for an average of 31.5 months, the 42% who were current smokers had a 44% increase in relative risk of disease progression and a 59% increase in relative risk of death, compared with nonsmokers. Smoking was an independent predictor of poor overall survival and poor progression-free survival, Dr. Steven E. Waggoner reported at the annual meeting of the Society of Gynecologic Oncologists.
Previous studies suggest that nearly 50% of women diagnosed with cervical cancer smoke. However, studies of the effects of smoking on outcomes in these patients have resulted in conflicting findings or were poorly controlled.
For this study, smoking behavior was reported prospectively on a questionnaire completed by patients. Those who smoked more ...