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Outpatient anticoagulation works without postponing surgery. (Study of Dalteparin).
PHILADELPHIA -- Surgical patients at high risk for thromboembolism were successfully eased off chronic anticoagulation without the need to postpone surgery using an outpatient dalteparin regimen.
In a study with 224 patients, the incidence of major bleeds was 6.6%, and the incidence of thrombotic events during follow-up was 3.6%, Dr. Michael J. Kovacs said at the annual meeting of the American Society of Hematology.
The standard bridging regimen has used unfractionated heparin, which requires several days of hospitalization.
The study done at 11 centers in Canada, included 112 patients on chronic warfarin therapy for a prosthetic heart valve and 112 patients on chronic warfarin therapy for atrial fibrillation, said Dr. Kovacs, a hematologist at the London Health Sciences Centre in Canada.
The study was funded by Pharmacia Corp., which makes dalteparin, a low--molecular-weight heparin.
The bridging regimen started 5 days before the scheduled surgery when patients stopped taking warfarin. Three days ...
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Source: HighBeam Research, Outpatient anticoagulation works without postponing surgery. (Study...