Probiotic combination reduces antibiotic-associated diarrhea and C. difficile in older adults.(ABSTRACTS OF INTEREST)

Publication: Original Internist

Publication Date: 01-MAR-08

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Reference: Hickson M, D'Souza A, Muthu N, et al. Use of probiotic Lactobacillus preparation to prevent diarrhea associated with antibiotics: randomized double blind placebo controlled trial. BMJ 2007;335:80; doi:10.1136/bmj.39231.599815.55 [Epub].

Design: Randomized, double-blind, placebo-controlled trial

Participants: 135 elderly inpatients (mean age 74 years old) who were prescribed antibiotics (single or multiple antibiotics, oral or intravenous)

Study Medication and Dosage: A 100 g (97 ml) probiotic yogurt drink (Actimel, Danone, France) containing Lactobacillus casei DN-114 001 (1.0 x 108...

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