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Epilepsia partialis continua can occur with widespread gliomatosis cerebri.
2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Epilepsia partialis continua can occur with widespread gliomatosis cerebri.
"We report an uncommon association of intractable epilepsia partialis continua that was the main presentation of widespread gliomatosis cerebri in two females. Both children had a preceding prolonged secondary generalized seizure 2-4 months before the evolution of epilepsia partialis continua, including recurrent clusters of left sided myoclonic twitching and sensory impairment. During these events, the children remained fully alert," researchers in Israel report.
"These seizures were corroborated by prolonged focal epileptic spike/wave discharges evident on the electroencephalograms (EEG). Cerebral magnetic resonance imaging (MRI) in the first patient demonstrated a wide area of increasing signals over the right frontocentral regions, along with diffuse cortical-subcortical infiltration impinging on the left hemisphere. In the second patient a cortical lesion was suspected.
"Evaluation for Rasmussen's encephalitis, focal cortical dysplasia, or a gliomatous process was conducted; the patients underwent a stereotactic brain biopsy in which the histologic findings were compatible with gliomatosis cerebri with diffuse widespread infiltration of glioma cells with no constitution of a circumscribed tumor mass. The first patient was treated with cranial radiation, chemotherapy, steroids, and combined antiepileptic therapy. The focal seizures gradually but markedly decreased in frequency, ...
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...Researchers from Germany performed "a clonal analysis of gliomatosis cerebri (GC), a rare disease characterized by diffuse, extensively...Oncology (Mitochondrial DNA as a clonal tumor cell marker: gliomatosis cerebri. J Neuro-oncol, 2003;61(1):1-5). The corresponding...
