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Vaginal vaccine prevents recurrent UTIs in trials. (Phase II Study).
CHICAGO -- The incidence of recurrent urinary tract infections in women was cut nearly in half over 6 months by the use of a vaginal mucosal vaccine in a phase II study of 54 women.
The vaccine, formulated into a vaginal suppository will next undergo efficacy testing when self-administered by women over the course of a year. It will also undergo additional efficacy testing in a larger, multicenter, phase III trial, Walter J. Hopkins, Ph.D., said while presenting a poster at the annual Interscience Conference on Antimicrobial Agents and Chemotherapy sponsored by the American Society for Microbiology.
The vaccine contains heat-killed bacteria from 10 different isolates obtained from women with recurrent urinary tract infections (UTIs). The panel of vaccine strains includes six different isolates of Escherichia coli and one isolate each of Enterococcus faecalis, Klebsiella Pneumoniae, Moganella morgan morganii and Proteus mirabilis. A total of 2 billion killed bacteria are contained in each suppository (200 million of each strain), formulated with a polyethylene glycol base, said Dr. Hopkins, an immunologist at the University of Wisconsin, Madison. The study was sponsored in part by the companies that ...
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Source: HighBeam Research, Vaginal vaccine prevents recurrent UTIs in trials. (Phase II Study).