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Bisphosphonate therapy reduces bone metastases, raises survival. (Breast Cancer Patients).
SAN ANTONIO -- Adjuvant bisphosphonate therapy in breast cancer patients appears to decrease the incidence of bone metastases and to reduce mortality, Dr. Trevor J. Powles said at the annual breast cancer symposium sponsored by the San Antonio Cancer Institute.
He presented the results of an international, double-blind, randomized trial involving 1,069 women with primary breast cancer who were randomized to receive 1,600 mg/day of oral clodronate or placebo for 2 years in addition to standard breast cancer therapies.
During the 2-year medication period, 12 patients on clodronate, a bisphosphonate that's not available in the United States, developed bone metastases, as did 28 patients in the placebo group. This represents a highly significant 56% reduction in the incidence of bone metastases in patients randomized to bisphosphonate therapy, noted Dr. Powles, head of the breast unit at the Royal Marsder. Hospital in London.
He characterized the study results as "encouraging" but in need of confirmation before making wholesale changes in practice. Dr. Powles noted that the National Surgical Adjuvant Breast and Bowel Project's B-37 trial will randomize several thousand breast cancer patients to 3 years of clodronate treatment or placebo. Moreover, ...
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Source: HighBeam Research, Bisphosphonate therapy reduces bone metastases, raises survival....