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Anthrax doesn't develop resistance to long-term Tx with Doxycycline. (In Vitro Study).

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| February 15, 2002 | Tucker, Miriam E. | COPYRIGHT 2002 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

CHICAGO -- Doxycycline appears to be superior to ciprofloxacin, or any other quinolone or macrolide, for long-term therapy or prophylaxis against anthrax, Dr. Itzhak Brook reported in a poster presentation at the annual Interscience Conference on Antimicrobial Agents and Chemotherapy sponsored by the American Society for Microbiology

Quinolones, macrolides, and doxycycline are all considered effective therapy against anthrax. But the development of antimicrobial resistance against these drugs by Bacillus anthracis could limit their usefulness in the event of any future bioterrorism attacks, said Dr. Brook of the Armed Forces Radiobiology Research Institute, Bethesda, Md.

In a study funded by the U.S. Department of Defense, Dr. Brook and his associates subjected a veterinary anthrax vaccine strain (B. anthracis Sterne) to 21 sequential subcultures in subinhibitory concentrations of doxycycline, ciprofloxacin, alatrofloxacin, and gatifloxacin. They also ran it ...

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