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CHICAGO -- Doxycycline appears to be superior to ciprofloxacin, or any other quinolone or macrolide, for long-term therapy or prophylaxis against anthrax, Dr. Itzhak Brook reported in a poster presentation at the annual Interscience Conference on Antimicrobial Agents and Chemotherapy sponsored by the American Society for Microbiology
Quinolones, macrolides, and doxycycline are all considered effective therapy against anthrax. But the development of antimicrobial resistance against these drugs by Bacillus anthracis could limit their usefulness in the event of any future bioterrorism attacks, said Dr. Brook of the Armed Forces Radiobiology Research Institute, Bethesda, Md.
In a study funded by the U.S. Department of Defense, Dr. Brook and his associates subjected a veterinary anthrax vaccine strain (B. anthracis Sterne) to 21 sequential subcultures in subinhibitory concentrations of doxycycline, ciprofloxacin, alatrofloxacin, and gatifloxacin. They also ran it ...