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Muromonab-CD3 (Systemic).
In the U.S. --
Orthoclone OKT3
In Canada --
Orthoclone OKT3
Monoclonal antibody
immunosuppressant
Description
Muromonab-CD3 (myoo-roe-MOE-nab cee-dee-three) is a monoclonal antibody. It is used to reduce the body's natural immunity in patients who receive organ (for example, kidney) transplants.
When a patient receives an organ transplant, the body's white blood cells will try to get rid of (reject) the transplanted organ. Muromonab-CD3 works by preventing the white blood cells from doing this.
The effect of muromonab-CD3 on the white blood cells may also reduce the body's ability to fight infections. Before you begin treatment, you and your doctor should talk about the good this medicine will do as well as the risks of using it.
Muromonab-CD3 is to be administered only by or under the immediate supervision of your doctor. It is available in the following dosage form:
Parenteral
Injection (U.S. and Canada)
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For muromonab-CD3, the following should be considered:
- Guidelines for the Optimal Use of Muromonab CD3 in Transplantation.
- Newspaper article from: Immunotherapy Weekly May 24, 1999 700+ words
...Schellekens, P.T.A. "Guidelines for the Optimal Use of Muromonab CD3 in Transplantation." Biodrugs, April 1999;11(4...authors' abstract of an article published in Biodrugs, "Muromonab CD3 (OKT3), the murine anti-CD3 monoclonal antibody...
- Antineoplastics: Leucoencephalopathy (first report for topotecan, clofarabine...
- Magazine article from: Reactions Weekly Anonymous January 10, 2009 700+ words
...months, which involved fludarabine, thiotepa, melphalan and muromonab CD3. Twenty-eight days after transplantation, he developed...leucoencephalopathy associated with topotecan, clofarabine or muromonab CD3. The WHO Adverse Reactions database did not contain any...
- PROCRIT (Epoetin alfa) INDICATED FOR THE TREATMENT OF ANEMIA IN CANCER PATIENTS...
- Press release article from: PR Newswire April 7, 1993 700+ words
...D., Clinical Associate Professor of Medicine, University of Pennsylvania School of Medicine, an investigator who conducted clinical...discovered and markets ORTHOCLONE OKT3 (muromonab-CD3), the first and only therapeutic...
- Simulect use results in significant reduction in transplant rejection.
- Newspaper article from: Health & Medicine Week June 14, 2004 700+ words
...Basiliximab (Simulect) versus Muromonab (OTK 3) in the setting of cyclosporine...article was prepared by Health & Medicine Week editors from staff and other...Copyright 2004, Health & Medicine Week via NewsRx.com & NewsRx...
- Study: Two-dose Zenapax reduced incidence of acute organ rejection.
- Newspaper article from: Blood Weekly June 20, 2002 700+ words
...function, and had cost benefits when compared with OKT3 (muromonab-CD3), another induction treatment used to prevent acute...assistant professor at the University of Maryland School of Medicine, Baltimore, MD. Patients treated with Zenapax had higher...
- Medicines: using them safely.(Adult Health Advisor 2005)
- Clinical Reference Systems January 1, 2006 700+ words
...right amount of medicine at the right time. * Keep all medicines out of the reach...directions for each medicine may be different. * Do not store medicines in a bathroom...bathroom may damage the medicine. Keep medicines in a cool, dry...
- Medicines: using them safely.(Senior Health Advisor)
- Clinical Reference Systems November 1, 2008 700+ words
...the right amount of medicine at the right time. * Keep all medicines out of the reach...bathroom may damage the medicine. Keep medicines in a cool, dry place...Safely stop taking a medicine. When used properly, medicines can be useful or...
- Report of Traditional Chinese Medicine Industry under, 2009.
- Press release article from: M2 Presswire May 28, 2009 700+ words
...traditional Chinese medicine pills and proprietary Chinese medicines. The traditional...proprietary Chinese medicines. The traditional Chinese medicine industry researched...traditional Chinese medicines play an important...modern Chinese medicine and pharmacology...
