Doxepin (Topical).

A commonly used brand name in the U.S. and Canada is Zonalon.

Description Topical doxepin (DOX-e-pin) is used to relieve itching in patients with certain types of eczema. It appears to work by preventing the effects of histamine, which is a substance produced by the body that causes itching.

Doxepin is available only with your doctor's prescription in the following dosage form:

 
   Topical 
      o Cream (U.S. and Canada) 
 

Before Using This Medicine In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For topical doxepin, the following should be considered:

Allergies -- Tell your doctor if you have ever had any unusual or allergic reaction to doxepin. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy -- Doxepin has not been studied in pregnant women. However, doxepin has not been shown to cause birth defects or other problems in animal studies.

Breast-feeding -- Doxepin passes into the breast milk. Oral doxepin has been shown to cause unwanted effects in the breast-fed baby. Therefore, it may be necessary for you to use another medicine or to stop breast-feeding during treatment with topical doxepin. Be sure you have discussed the risk and benefits of the medicine with your doctor.

Children -- Studies on this medicine have …