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Phase III Study Shows Avastin Plus Interferon Therapy Nearly Doubled Median Progression-Free Survival in Patients With Previously Untreated Advanced Kidney Cancer.(Clinical report)
- First Antibody That Specifically Inhibits VEGF to Show Improvement in a Phase III Kidney Cancer Trial -
CHICAGO -- Genentech, Inc. (NYSE:DNA) today announced that a Roche-sponsored, randomized placebo-controlled Phase III clinical study of Avastin([R]) (bevacizumab) in combination with interferon alfa-2a therapy increased the median time patients with first-line metastatic renal cell carcinoma (mRCC) lived without their cancer growing or spreading as defined by progression-free survival (PFS). Patients receiving Avastin plus interferon alfa-2a therapy experienced a 59 percent improvement in PFS (based on a hazard ratio of 0.63) compared to those receiving interferon alfa-2a therapy alone.
The American Society of Clinical Oncology (ASCO) today featured the results of the trial, known as AVOREN, in a press briefing at its 43rd Annual Meeting in Chicago. These data were also highlighted in a plenary session by Bernard Escudier, M.D., head of the immunotherapy and innovative therapy unit at the Gustave-Roussy Institute, Paris, France (Abstract #3 - Monday, June 4, 2:30 p.m. CDT).
"Patients with metastatic renal cell carcinoma often express elevated levels of vascular endothelial growth factor, or VEGF," said Dr. Escudier.…
- Antigenics updates business strategy and outlines timeline for the analysis of...
- News wire article from: Chemical Business Newsbase December 6, 2005 700+ words
...of data from its kidney cancer trial of Oncophage...oncologist of its Phase III trial in renal cell...Oncophage from both the kidney cancer and melanoma Phase III trials. These tests...the outcome of the kidney cancer trial, Antigenics...
- Sorafenib doubles progression-free survival in Phase III kidney cancer trial.
- News wire article from: Asia Africa Intelligence Wire May 14, 2005 700+ words
...was well tolerated in an ongoing Phase III trial in patients with advanced...than 900 patients with advanced kidney cancer, who had previously failed one...national, placebo-controlled Phase III study. Nearly 120 sites accrued...
- AEterna Presents Status on Neovastat Phase III Trials in Kidney Cancer and Lung...
- Press release article from: PR Newswire June 2, 2003 700+ words
...on this trial. Current Phase III trial in kidney cancer AEterna is currently conducting...randomized placebo controlled Phase III trial for renal cell carcinoma...in Canada for the current Phase III trial in kidney cancer. Renal cell carcinoma is...
- AEterna presents status on Neovastat Phase III trials in kidney cancer and lung...
- Press release article from: PR Newswire June 2, 2003 700+ words
...on this trial. Current Phase III trial in kidney cancer AEterna is currently conducting...randomised placebo controlled Phase III trial for renal cell carcinoma...in Canada for the current Phase III trial in kidney cancer. Renal cell carcinoma is...
- Antigenics Announces Partial Clinical Hold on Phase III Trials for Kidney...
- Press release article from: Business Wire September 3, 2003 700+ words
...Currently Enrolled in Phase III Trials Will Continue...partial clinical hold the Phase III trials of Oncophage under...which includes trials in kidney cancer and metastatic melanoma...already enrolled in the Phase III studies could proceed...
- Antigenics announces partial clinical hold on Phase III trials for kidney...
- News wire article from: Asia Africa Intelligence Wire September 3, 2003 700+ words
...placing on partial clinical hold the Phase III trials of Oncophage under its investigational...application, which includes trials in kidney cancer and metastatic melanoma. The FDA...patients already enrolled in the Phase III studies could proceed with vaccination...
- Bayer and Onyx Initiate Pivotal Phase III Clinical Trial in Kidney Cancer;...
- Press release article from: PR Newswire October 25, 2003 700+ words
...an international, multi- center Phase III trial to further evaluate the safety...of advanced renal cell carcinoma (kidney cancer). "We are optimistic that BAY...said Ronald Bukowski, M.D., the Phase III study's lead investigator and director...
- BAY 43-9006 Shown to Delay Disease Progression in Phase III Study in Advanced...
- Press release article from: PR Newswire March 21, 2005 700+ words
...companies' pivotal Phase III trial in patients with advanced kidney cancer. Based on its analysis...Orlando, Florida. Phase III Summary The multi...placebo-controlled Phase III study recently finished...patients with advanced kidney cancer. The primary ...
- AEterna has Completed Patient Recruitment for its International Phase III...
- Press release article from: PR Newswire December 19, 2001 700+ words
...this international Phase III trial in renal...common type of kidney cancer in adults. There...effects. AEterna's Phase III renal cell carcinoma...undergoing two Phase III clinical trials...treatment of lung and kidney cancer, and one Phase...
- AEterna has completed Patient Recruitment for its International Phase III...
- Press release article from: PR Newswire December 18, 2001 700+ words
...this international Phase III trial in renal...common type of kidney cancer in adults. There...effects. AEterna's Phase III renal cell carcinoma...undergoing two Phase III clinical trials...treatment of lung and kidney cancer, and one Phase...
Source: HighBeam Research, Phase III Study Shows Avastin Plus Interferon Therapy Nearly Doubled...
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