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Metformin matches insulin in Tx of A2 gestational diabetes.(Obstetrics)
RENO, NEV. -- Metformin controlled blood glucose levels as well as insulin in patients with class A2 gestational diabetes, and was not associated with any adverse maternal or neonatal outcomes, according to a randomized trial with 63 patients.
"We found that metformin appears to be an acceptable way to achieve glucose homeostasis in the A2 diabetes patient," Christian Briery, M.D., said at the annual meeting of the Society for Maternal-Fetal Medicine.
The study enrolled pregnant patients who were at greater than 11 weeks' gestation but less than 35 weeks' gestation. The women received a starting dose of insulin of 0.7 U/kg daily, in three doses (31 patients) or 500 mg metformin twice daily (32 patients).
The patients were then monitored weekly to see that they achieved a postprandial blood glucose level of less than 120 mg/dL and a fasting glucose level of 60-90 mg/dL, said Dr. Briery of the University of Mississippi Medical Center, Jackson.
In blood glucose measurements taken by the patients at home, the mean fasting glucose level was 96.8 mg/dL in the insulin-treated patients versus 92.6 mg/dL in the metformin-treated group.
Similarly, the researcher reported that the mean postprandial ...
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Source: HighBeam Research, Metformin matches insulin in Tx of A2 gestational...