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Hypoplastic left heart syndrome: karyotyping is key.(Obstetrics)

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| April 01, 2005 | Finn, Robert | COPYRIGHT 2005 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

RENO, NEV. -- Fetuses with hypoplastic left heart syndrome and normal chromosomes are unlikely to die in utero, according to a retrospective study of 176 fetuses diagnosed prenatally with the disorder.

Of these fetuses, which were diagnosed over a 12-year period, 133 were live born, 32 underwent therapeutic abortion, and 3 died in utero. The outcome for eight of the fetuses is unknown, Rebecca H. Allen, M.D., and her associates wrote in a poster presentation at the annual meeting of the Society for Maternal-Fetal Medicine.

Of the 3 fetuses that died in utero, 1 had trisomy 13, 1 had trisomy 18, and 1 was not karyotyped. Both of the fetuses with abnormal karyotypes had other anomalies detected by ultrasound. The third had no anomalies, but was one of triplets. Only 2 of the 133 live-born fetuses had abnormal ...

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