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Alcohol, DES exposure may be fibroid risk factors.(Gynecology)
BETHESDA, MD. -- Alcohol, diethyl-stilbestrol exposure, and family history are potential risk factors for fibroids, according to several recent studies presented at an international conference on uterine leiomyoma research.
Data from one study of nearly 1,500 women conducted by the National Institute of Environmental Health Sciences identified prenatal diethylstilbestrol (DES) exposure and young age at menarche as fibroid risk factors. The study's purpose was to explore the epidemiology of fibroids by examining hormonal, inflammatory, and metabolic risk factors, reported Donna Day Baird, Ph.D.
Dr. Baird, a senior epidemiologist with the NIEHS, and her colleagues used data from the Nurses' Health Study and the Black Women's Health Study to identify a random sample of 1,482 pre- and post-menopausal women (aged 39-49 years) who had fibroids. The presence of fibroids was confirmed by ultrasound (73%), surgery (6%), or self-reports (21%).
Results from the study supported previously known fibroid risk factors of African American ethnicity and age older than 35 years. Approximately half the African American women had been diagnosed with fibroids before enrolling in the study. Among all the women without a previous diagnosis, fibroids also were more common among African American women, especially among the younger age groups.
In a logistic regression analysis, the cumulative incidence of fibroids among black women was 60% at age 35 years and 80% by the age of menopause. Among white women, the incidence was less than 40% at age 35 years and almost 70% by the age of menopause.
Prenatal exposure to DES was significantly associated with the presence of fibroids, Dr. Baird said at the conference sponsored by the National Institutes of Health.
The women in the study all had the potential for DES exposure, since they were born during the time when DES was used as potential therapy for problem pregnancies. The exposure data were based on self-reports, categorized as "yes," "no," and "maybe." Five black women reported definite exposure, and all five had fibroids, as did 14 of 19 white women who reported exposure. "Adjusting for age, there is a significant association between DES exposure and the development of fibroids, and it is stronger for large fibroids than for small fibroids," Dr. Baird said.
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Source: HighBeam Research, Alcohol, DES exposure may be fibroid risk factors.(Gynecology)