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The risk of fairing and suffering a fracture may increase in adults over age 50 if they are taking SSRI (selective serotonin reuptake inhibitor) medication for depression. A new study from the Archives of. Internal Medicine monitored 5,008 adults, 137 of whom were taking SSRIs such as Lexapro, Prozac and Zoloft. Daily use of the drugs was associated with a doubted risk of fragility fractures and also failing and the higher the SSRI dose, the greater the subjects' ...