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Administration route shapes the effects of IL-12-expressing dendritic cells.

Cancer Vaccine Week

| June 28, 2004 | COPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 JUN 28 - (NewsRx.com & NewsRx.net) -- Administration route shapes the effects of IL-12-expressing dendritic cells.

According to published research from the United States, "gene-modified dendritic cells (DC) provide unique therapeutic strategies for prostate cancer; however, the comparative evaluation of specific delivery options using appropriate preclinical models has not been described. In this study, bone marrow-derived DC were genetically engineered to express high levels of interleukin-12 (IL-12) with or without the costimulatory molecule B7-1, by ex vivo infection with recombinant adenoviral vectors."

"We used an orthotopic metastatic mouse…

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Source: HighBeam Research, Administration route shapes the effects of IL-12-expressing dendritic...

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