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Endothelial cell-specific human antibodies might retard tumor growth.

Cancer Gene Therapy Week

| June 28, 2004 | COPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 JUN 28 - (NewsRx.com & NewsRx.net) -- Endothelial cell-specific human antibodies might retard tumor growth.

According to scientists in Germany, "we have isolated single-chain Fv fragments directed against human endothelial cells from a novel fully synthetic human scFv library (scFv 479). This library was constructed using the variable germline segments DP47 and DPkappa9 as scaffolds. Complementarity-determining regions 3 (CDR) of the variable heavy and light chain were introduced with a length of 9 amino acid residues."

"In total, 16 amino acid positions of all 6 CDRs exposed in the antigen-binding site were randomized and the library was produced from …

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Source: HighBeam Research, Endothelial cell-specific human antibodies might retard tumor growth.

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