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Warn patients: St. John's Wort may affect metabolism of cancer drug.(Clinical Rounds)
MIAMI BEACH -- St. John's Wort can alter the clinical effectiveness of the cancer drug imatinib and could lead to a relapse of disease among patients taking both products concomitantly, Reginald Frye, Ph.D., reported at the annual meeting of the American Society for Clinical Pharmacology and Therapeutics.
The herbal product hastens the elimination of imatinib (Gleevec) from the body, reducing the amount of the cancerfighting agent in a patient's system, said Dr. Frye of the University of Florida, Gainesville.
Referred to as a "magic cancer bullet" because of its efficacy in treating chronic myelogenous leukemia and because patients can take it daily at home, imatinib inhibits the protein tyrosine kinases associated with the oncogene Bcr-Abl. The drug is predominantly metabolized by cytochrome P450 3A. Previous studies have shown that St. John's Wort, often used as an alternative therapy for anxiety and depression, alters the activity of that enzyme.
To determine the effect of St. John's Wort on the pharmacokinetics of imatinib, Dr. Frye and former colleagues at the University of Pittsburgh Cancer Institute, where the research was conducted, evaluated the impact of concomitant use of both preparations in 12 healthy, nonsmoking subjects (six males, six females). ...
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Source: HighBeam Research, Warn patients: St. John's Wort may affect metabolism of cancer...