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Study of six women: only negligible amount of glyburide found in breast milk.(Obstetrics)
MIAMI BEACH -- Only a negligible amount of glyburide was found in the breast milk of six women who were taking the drug to treat type 2 diabetes, Dr. Denice Feig reported.
Investigators analyzed the breast milk of the women, who had taken a single 5-mg dose of the oral hypoglycemic. They determined that the extent of transfer was below the level of detection, she said in a poster presentation at the annual meeting of the American Society for Clinical Pharmacology and Therapeutics.
The usual glyburide dose is 5 mg twice daily. Some patients take less, and some take up to 10 mg twice daily, said Dr. Feig, head of the Diabetes and Endocrinology in Pregnancy Program at Mount Sinai/University Health Network in Toronto.
At present, women are advised not to breast-feed while on oral hypoglycemics, but that recommendation reflects a lack of evidence-based data regarding the extent of transfer of these drugs into breast milk.
"There are not a lot of data out there. The recommendation is based largely on an old study using tolbutamide--an old sulfonylurea--that showed crossing into breast milk. We also know that the old sulfonylureas crossed the placenta," Dr. Feig said. "Ours is the first study [of breast milk] looking at glyburide, which has also been shown not to cross the placenta."
To determine the extent of glyburide transfer. ...
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Source: HighBeam Research, Study of six women: only negligible amount of glyburide found in...