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Phase III treatment trials: breast ca survival lags in African Americans.(News)
ORLANDO, FLA. -- African Americans with breast cancer had significantly worse survival rates than patients of other races in major phase III-treatment trials done in the United States.
"The difference in survival persists after adjustment for tumor status, demographics, socioeconomic status, and treatment, Dr. Kathy S. Albain said at the annual meeting of the American Association for Cancer Research.
"We must explore other possible explanations, such as molecular biologic, molecular epidemiologic, pharmacologic, and hormonal causes," said Dr. Albain, who is professor of medicine and director of the breast research program at the Cardinal Bernardin Cancer Center, Loyola University Chicago Medical Center, Maywood, Ill.
Evidence for survival disparities among patients with breast cancer came from data collected by two study groups. The National Surgical Adjuvant Breast and Bowel Project enrolled more than 8,000 women with node-negative cancer and more than 5,000 women with node-positive cancer.
In an analysis that adjusted for age, treatment, and tumor size, African Americans had about a 20% worse survival rate compared with all other patients, regardless of node status, according to Dr. Albain. This difference was statistically significant.
African Americans also had about a 10% increased risk of death due to breast cancer, but this difference was not statistically significant.
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Source: HighBeam Research, Phase III treatment trials: breast ca survival lags in African...