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Constantinople was the capital of the Byzantine Empire from AD 330 until the fifteenth century. Some of the early important buildings from that period still survive, including Hagia Sophia, a Byzantine church built on the site of an earlier church in AD 537 and later turned into the Aya Sofya mosque. The metropolis and the empire went into decline in the thirteenth century, and by the end of the fourteenth century the Muslim Osman dynasty--the Ottomans--had occupied all but the capital. The city fell in 1453, and its name was changed to Istanbul.
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The Ottoman Empire flourished, and by the beginning of the sixteenth century the three holiest cities of Islam--Mecca, Medina, and Jerusalem--were under its control. Istanbul, largely because of its location on the border of Europe and Asia, was a crossroads of cultures. Among the groups inhabiting the old city were Muslims, Greeks, Jews, and Armenians. On the site of the former Byzantine acropolis, the Ottomans constructed a new palace, Topkapi, which ...
Source: HighBeam Research, Istanbul in Amsterdam.(historic exhibition)