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Serotonin agonist m-CPP reduces craving in cocaine addicts. (meta-chlorophenylpiperazine)

The Brown University Digest of Addiction Theory and Application

| August 01, 1997 | This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

Evidence suggests that serotonin may play a role in cocaine craving among substance abusers, according to an article published in The American Journal on the Addictions.

Investigators Laure Buydens-Branchey, M.D., and colleagues from the SUNNY Health Science Center in Brooklyn, say that the administration of meta-chlorophenylpiperazine (m-CPP), a serotonin agonist, can significantly reduce feelings of craving in cocaine addicts, suggesting that serotonin systems play a role in the complex experience called craving. Studies in laboratory rats have shown that manipulations of the serotonin brain system will reduce cocaine self-administration.

The investigators studied response to m-CPP in a group of 31 male cocaine addicts who were hospitalized in an inpatient drug…

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