DNA damage response.(Foundations)

"In 1986, I was trying to identify a RecA-related protein in Sacchoromyces cerevisiae whose abundance increased in response to DNA damage. I expected a recombinase but when I cloned the gene, it encoded ribonucleotide reductase, which cross-reacted with the antibody I used. I was initially depressed by these findings. However, I soon realized this meant that eukaryotes took great care to ensure that DNA replication was protected in response to DNA damage. This Northern blot …