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Ethnicity, NT and down syndrome risk: consider crown-rump length.(Obstetrics)
PARIS -- An absent nasal bone at 11-14 weeks' gestation is strongly related to the presence of chromosomal defects, Dr. Kypros H. Nicolaides reported at the 13th World Congress on Ultrasound in Obstetrics and Gynecology.
Among fetuses with absent nasal bone, the likelihood of Down syndrome can be further delineated by racial/ethnic group, gestational age, and the degree of nuchal translucency, said Dr. Nicolaides, director of the fetal medicine center at King's College, London.
Of 3,788 fetuses scanned by ultrasound at 11-14 weeks' gestation, the nasal bone was absent in 2.8% who were chromosomally normal, 66.9% with trisomy 21, and 33.0% with other chromosomal defects.
Among the 3,358 chromosomally normal fetuses, the likelihood of having an absent nasal bone differed significantly by the mother's ethnic origin, ranging from 2.5% of whites to 6.8% of Asians to 10.4% for Afro-Caribbeans.
Other factors predicting absent nasal bone in karyotypically normal fetuses included greater crown-rump length (from 4.6% for a CRL of 45-54 mm to 1.0% for CRL 75-84 mm) and nuchal translucency thickness (2% for NT below 2.5 mm to 12% for NT ...
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Source: HighBeam Research, Ethnicity, NT and down syndrome risk: consider crown-rump...