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'D-zone' clue key to clindamycin-resistant MRSA: test inducible resistance.(Clinical Rounds)
ASPEN, COLO. -- Physicians should make sure their microbiology lab is testing for both inducible and constitutive resistance to clindamydn when they send samples for susceptibility testing, Dr. Carol J. Baker said at a conference on pediatric infectious diseases sponsored by Children's Hospital, Denver.
With the rise in methicillin-resistant Staphylococcus aureus (MRSA), susceptibility testing has become routine. But unless the lab takes special care, the report may say that the patient's S. aureus is susceptible to clindamycin when actually it is not,
In constitutive resistance, the microbe is. clearly resistant to both erythromycin and clindamycin, and the lab will be able to pick this up using any susceptibility test, she explained at the meeting, which was also sponsored by the University of Colorado.
The problem is with inducible resistance. During ordinary testing, the microbe appears to be resistant to erythromycin and susceptible to clindamycin, but once the patient is ...
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