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Raloxifene tx not linked to gallbladder disease: posthoc analysis of major study.(Gynecology)

OB GYN News

| November 01, 2003 | Sullivan, Michele G. | COPYRIGHT 2003 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

MIAMI BEACH -- Raloxifene therapy for 4 years was not associated with any increase in new-onset gallbladder disease or worsening of existing gallbladder disease in postmenopausal women with osteoporosis, Dr. Deborah Grady reported in a poster session at the annual meeting of the North American Menopause Society.

The finding, a posthoc analysis of the Multiple Outcomes of Raloxifene Evaluation (MORE) trial, is important because some observational studies have suggested that postmenopausal estrogen use increases the risk of gallbladder disease by two to four times, said Dr. Grady of the University of California, San Francisco.

The MORE study randomized 7,705 postmenopausal women to placebo or raloxifene (Evista) in doses of 60 mg/day or 120 mg/day All women also received about 500 mg/day elemental calcium and 400-600 IU of ...

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