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Antibiotic tx before prolapse, incontinence surgery cuts UTIs: macrobid vs. placebo.(News)

OB GYN News

| November 01, 2003 | McNamara, Damian | COPYRIGHT 2003 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

HOLLYWOOD, FLA. -- Prophylaxis with the antibiotic Macrobid was tied to significantly fewer Symptomatic urinary tract infections than was placebo after surgery for pelvic organ prolapse and/or stress urinary incontinence.

This difference between groups was found at the time of suprapubic catheter removal, but was no longer significant at follow-up 6-8 weeks after surgery; said Dr. Dorothy N. Kamnmerer-Doak at the annual meeting of the American Urogynecologic Society.

In this double-blind trial, researchers assessed 414 women at six centers. All participants had a negative preoperative urine culture. A total of 202 women were randomized to receive Macrobid (nitrofurantoin) 100 mg / day, and 212 received placebo. The mean age was 54 years, the mean parity was 2.5, and most of the participants were white.

There were no significant differences between groups in terms of demographics, compliance, or perioperative complications, said Dr. ...

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