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One-fourth of malformations seen on first-trimester US: study of almost 10,000 women.(News)

OB GYN News

| October 15, 2003 | Tucker, Miriam E. | COPYRIGHT 2003 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

PARIS -- Although current ultra-sonographic approaches can detect a large proportion of anomalies during the first trimester, most will still remain undetected until later in gestation or after birth, reported Dr. Anne-Catherine Shalmi of Rigshospitalet, Copenhagen.

Data from the Copenhagen First Trimester Study, in which 9,956 low-risk pregnant women underwent nuchal translucency (NT) and full anomaly scanning at 11-14 weeks' gestation, suggest that fewer than one in four anomalies can be detected during the first trimester, even by experienced sonographers. A second scan is still needed at 18-23 weeks.

"The longer you wait, the more you can see," Dr. Shalmi noted at the 13th World Congress on Ultrasound in Obstetrics and Gynecology.

Full organ system scanning at 11-14 weeks was done in 9,917 fetuses; 81% were scanned transabdominally and transvaginally. A total of 32 serious malformations were seen. Aneuploidy was associated with the malformation in 6 of the cases. NT testing identified aneuploidy in an ...

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