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PARIS -- Although current ultra-sonographic approaches can detect a large proportion of anomalies during the first trimester, most will still remain undetected until later in gestation or after birth, reported Dr. Anne-Catherine Shalmi of Rigshospitalet, Copenhagen.
Data from the Copenhagen First Trimester Study, in which 9,956 low-risk pregnant women underwent nuchal translucency (NT) and full anomaly scanning at 11-14 weeks' gestation, suggest that fewer than one in four anomalies can be detected during the first trimester, even by experienced sonographers. A second scan is still needed at 18-23 weeks.
"The longer you wait, the more you can see," Dr. Shalmi noted at the 13th World Congress on Ultrasound in Obstetrics and Gynecology.
Full organ system scanning at 11-14 weeks was done in 9,917 fetuses; 81% were scanned transabdominally and transvaginally. A total of 32 serious malformations were seen. Aneuploidy was associated with the malformation in 6 of the cases. NT testing identified aneuploidy in an ...