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Zoloft with pimozide contraindicated. (FDA, Pfizer Warning).
At the request of the U.S. Food and Drug Administration, Pfizer has issued a warning on possible interaction between its drug sertraline (Zoloft) and the antipsychoric drug pimozide (Orap).
Pimozide is indicated for the suppression of severe motor and vocal tics due to Tourette's syndrome, only after the failure of other treatments. It is manufactured by Gate Pharmaceuticals.
Pfizer's letter to health care professionals informs them of a change in the prescribing information for sertraline tablets and oral concentrate. Under the contraindications section, it now states "concomitant use [of sertraline] in patients taking pimozide is contraindicated."
The interaction between pimozide and sertraline was brought to light in the "Phase 1 Open Study Designed to ...
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Source: HighBeam Research, Zoloft with pimozide contraindicated. (FDA, Pfizer Warning).