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NSAIDs, aspirin cut colorectal ca risk by one-third when use exceeds 2 years. (Metaanalysis of 13 Studies).
SEATTLE -- Regular use of aspirin or NSAIDs for longer than 2 years appears to reduce the risk of colorectal cancer by one-third, Dr. Jia-Qing Huang said at the annual meeting of the American College of Gastroenterology.
This was a central finding of his metaanalysis of eight large case-control and five cohort studies. Another key finding was that the magnitude of protection afforded by regular use of aspirin was equal to that provided by NSAIDs, said Dr. Huang of McMaster University, Hamilton, Ont.
Prior epidemiologic data have suggested that regular use of these agents lowers the risk of developing colorectal tumors. Animal studies have shown a 40%-60% relative risk reduction.
The aim of the metaanalysis was to address two key unanswered questions: the actual magnitude of the protective effect in patients, and the duration of use required to obtain this benefit. These questions assume importance because of the urgent need to develop a proven means of colorectal cancer prevention, Dr. Huang said.
He cited the "staggering" cost of managing the disease: an estimated $6.5 billion annually in the United States, where there are nearly ...
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Source: HighBeam Research, NSAIDs, aspirin cut colorectal ca risk by one-third when use exceeds...