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Antiphospholipid pregnancy outcomes improving. (Neuropsychological Problems Possible).
NEW ORLEANS -- The live birthrate of neonates born to women with primary antiphospholipid syndrome has risen, and their complications stem mostly from prematurity.
Those findings emerged from two presentations given at the Third International Conference on Sex Hormones, Pregnancy and the Rheumatic Diseases.
Complications from prematurity, rather than maternal disease, accounted for the adverse outcomes of 71 neonates born to women with primary antiphospholipid syndrome (APS), said Dr. Angela Tincani of the University of Milan.
The number of these newborns with intraventricular hemorrhage, periventricular leukomalacia, respiratory distress syndrome, bronchopulmonary dysplasia, retinopathy, and the number admitted to a neonatal intensive care unit did not differ in comparison with 71 control newborns who were matched for gestational age, birth weight, mode of delivery, and obstetric complications.
Overall, 32% of the newborns were premature.
Dr. Tincani said that some case reports have documented thrombosis in infants of APS mothers, but none of the infants in Dr. Tincani's series had a thrombosis. All of the women were treated for primary APS during pregnancy; women in the last 10 years of the study period received heparin and aspirin.
Previous reports did not establish whether maternal antibodies had any effect on the neonate. Some studies, including Dr. Tincani's, suggest that systemic lupus erythematosus--related antibodies, such as anti-Ro and anti-La, but ...
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