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Low-molecular-weight heparins in pregnancy may cause less bone loss. (Literature Review).

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| February 01, 2003 | Evans, Jeff | COPYRIGHT 2003 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

NEW ORLEANS -- The antithrombotic low-molecular-weight heparins may cause less osteoporosis during pregnancy than unfractionated heparins, according to Dr. Munther Khamashta.

He reviewed all of the available literature on osteopenia and osteoporosis in pregnancy caused by antithrombotic agents. One review article of antithrombotic agents during pregnancy noted that a reduction of bone mineral density occurs in up to 30% of pregnant women receiving unfractioned heparin (UH), causing symptomatic vertebral fractures in 2%-3% of such women, he said at the Third International Conference on Sex Hormones, Pregnancy and the Rheumatic Diseases.

The use of the low-molecular-weight heparins (LMWHs) dalteparin, enoxaparin, nadroparin, reviparin, and tinzaparin resulted in only one vertebral fracture in 486 pregnancies at 21 ...

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