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ORLANDO, FLA. -- Premature cardiovascular disease can be added to the list of adverse results stemming from athletic amenorrhea, Dr. Anne Zeni Hoch said at the annual meeting of the American Academy of Physical Medicine and Rehabilitation.
The chain reaction of hormone imbalances brought on by athletic amenorrhea often results in early menopause, and one result of that is a higher risk of heart disease, said Dr. Hoch of the Women's Sports Medicine Program at the Medical College of Wisconsin, Milwaukee.
While it is common to hear of a triad consisting of amenorrhea, eating disorders, and osteoporosis, she said that endothelial dysfunction should be added to form a "tetrad."
Athletic amenorrhea, the condition caused by the combination of excessive exercise, caloric restriction, low body fat, and low levels of leptin, sets off the series of adverse events, she said. They start with reduced secretion of gonadotropin-releasing hormone, which brings lower levels of luteinizing hormone, which can lead to ovarian shutdown. With that comes lower levels of estrogen and early menopause, which could lead to brachial artery dysfunction and to a greater risk of heart disease.
To study this link, Dr. Hoch and her colleague Dr. David Gutter-man looked at 32 women--10 of whom had been amenorrheic for an average of 2.3 years, 11 who had been oligomenorrheic for an average of 6.2 years, and 11 eumenorrheic control patients. All of the women were between 18 and 35 years of age and ran at least 25 miles per week.
Their brachial analysis of the ...
Source: HighBeam Research, Athletic amenorrhea may increase risk of heart disease. (Endothelial...